Use of haloperidol and risperidone in highly aggressive Swiss Webster mice by applying the model of spontaneous aggression (MSA)


  1. Highlights
  2. Abstract
  3. Abbreviations
  4. Keywords
  5. 1. Introduction
  6. 2. Material and methods
  7. 3. Results
  8. 4. Discussion
  9. 5. Conclusions
  10. Conflict of interest
  11. Sources of funding
  12. Acknowledgement
  13. References

Figures (6)

  1. Fig. 1. Experimental design of the model of spontaneous aggression and treatment with…
  2. Fig. 2. Selection and division into behavioral categories—(A) selection of animals by…
  3. Fig. 3. Evaluation of the immobility time of the animal through the tail suspension…
  4. Fig. 4. Evaluation of motor activity (A and B) and exploratory activity (C and D) of…
  5. Fig. 5. Evaluation of the total number of attacks in all groups by shooting for 30min…
  6. Fig. 6. Pattern of aggressive behavior quantified through measurement (cm2) of the…

Behavioural Brain Research

Volume 301, 15 March 2016, Pages 110-118Behavioural Brain Research

Research reportUse of haloperidol and risperidone in highly aggressive Swiss Webster mice by applying the model of spontaneous aggression (MSA)

Author links open overlay panelViviane Muniz da SilvaFragosoaLuanda YanaanHoppeaTânia Cremonini deAraújo-JorgeaMarcos José deAzevedoaJerônimo Diego de SouzaCamposbCélia MartinsCortezcGabriel Melo deOliveirab rights and content

Aggression is defined as the act in which an individual intentionally harms or injures another of their own species. Antipsychotics are a form of treatment used in psychiatric routine. They have been used for decades in treatment of patients with aggressive behavior. Haloperidol and risperidone promote the control of psychiatric symptoms, through their respective mechanisms of action. Experimental models are obtained by behavioral, genetic, and pharmacological manipulations, and use a reduced number of animals. In this context, we applied the model of spontaneous aggression (MSA), originating the presence of highly aggressive mice (AgR) when reassembled in adulthood. We administered haloperidol and risperidone in escalating doses, for ten consecutive days. Using positive and negative control groups, we evaluated the effectiveness of these drugs and the reversal of the aggressive behavior, performing the tail suspension test (TST) and open field test (OFT) on 10th day of treatment and 10 days after its discontinuation. The results showed that both antipsychotic drugs were effective in AgR and reversed the aggressive phenotype, reducing the number of attacks by AgR and the extent of lesions in the subordinate mice (AgD) exposed to the pattern of aggressive behavior (PAB) of the aggressors. This conclusion is based on the reduction in the animals' motor and exploratory activity, and on the reversal of patterns of aggressive behavior. The association between the MSA and experiments with other therapeutic protocols and different antipsychotics can be an important methodology in the study of aggressive behavior in psychiatric patients.